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KMID : 0350519960490041293
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Journal of Catholic Medical College
1996 Volume.49 No. 4 p.1293 ~ p.1304
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Expression of Gonadotropin-releasing Hormone receptor in Human Uterine Endometrial and
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Abstract
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Gonadotropin-releasing hormone (Gn-RH) can case regression of hormone-dependent human tumors, including uterine endometrial and ovarian carcinomas. These effects were thought to be mediated through the inhibition of gonadotropic and steroid
hormone
from
the hypothalamus. But, in addition to its classic hypophysiotropic action, Gn-RH might play a role as a modulator of activity in the brain and many peripheral organs. It has been reported that this analog has a direct inhibitory effect on the
tumor
and
that the specific binding sites for Gn-RH were demonstrated in certain tumor responsive to Gn-RH.
@ES The results were as follows:
@EN 1. Gn-RH receptor mRNA was detected in all normal endometrium and abnormally proliferative endometrium presenting dysfunctional bleeding, but not all in endometrial carcinomas (83%). And, Gn-RH receptor mRNA was detected in less than 40% in
normal
myometrium and myomas.
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KEYWORD
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